ADMA in preeclampsia

Preeclampsia is currently believed to be a consequence of impaired endothelium-dependent regulation of uterine and systemic maternal blood flow. These mechanisms have helped to explain the occurrence of the three major clinical symptoms of pre-eclampsia, hypertension, edema, and proteinuria, as well as the risk of intrauterine growth retardation and misconception, which are believed to be the results of impaired placental perfusion.
Pregnant women developing preeclamspia have been shown to be characterized by endothelial dysfunction, whereas healthy pregnant women have an intact endothelial function.
In several studies from Western European countries, elevated ADMA concentration was identified to be a risk marker for preeclampsia [33-35, 62, 63]. Thus, quantification of ADMA may be a diagnostic marker for women at risk of developing preeclampsia.